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Safety and side effects.

Possible side effects of PREVNAR 20® include muscle pain, fatigue, headache, and joint pain.

What are the possible side effects of Prevnar 20?

For adults, the most common side effects reported in clinical trials were:

  • Pain at the injection site
  • Muscle pain
  • Fatigue
  • Headache
  • Joint pain

For adults under 60 years of age, swelling at the injection site was also common.

If you have any questions about the safety information, or want more details, talk to your doctor or pharmacist.

What should I ask my doctor or pharmacist about PREVNAR 20®?

What should I ask my doctor or pharmacist about Prevnar 20?

Because pneumococcal pneumonia can strike any time of year, it's important to understand your risk and ask your doctor or pharmacist if Prevnar 20 is right for you. Here's a guide to review and bring with you the next time you see your doctor or pharmacist.

Check out our doctor discussion guide

Prevnar 20 should not be given to anyone with a history of severe allergic reaction to any component of Prevnar 20 or to any diphtheria toxoid.

Adults with weakened immune systems may have a lower response to Prevnar 20. Safety data are not available for these groups. Your healthcare provider can tell you if Prevnar 20 is right for you.

Patients should always ask their healthcare providers for medical advice about adverse events. You are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). Visit or call 1-800-822-7967.